Combination medicines containing narcotic analgesics nar-KOT-ik an-al-JEE-zicks such as tramadol TRA-ma-dole and acetaminophen a-seat-a-MIN-oh-fen are used to relieve pain. An opioid analgesic and acetaminophen used together may provide better pain relief than either medicine used alone. In some cases you may get relief with lower doses of each medicine.